Research article summary (published 29 Sep 2009):

Predictors of clinical improvement in a randomized effectiveness trial for primary care patients with panic disorder.

Full Abstract

This study's aim was to prospectively examine and identify a model of demographic, clinical, and attitudinal variables that impact improvement among patients with panic disorder. Subjects were 232 primary care patients meeting criteria for DSM-IV panic disorder. Eligible patients were randomly assigned to a collaborative care intervention or to treatment as usual. Assessments occurred at 3-month intervals during the course of 1 year. In final multivariate logistic regression models, patients with higher anxiety sensitivity and higher neuroticism scores at baseline were less likely to show clinical improvement (using a criterion of 20 or less on the Anxiety Sensitivity Index) at 3 months. Those who were non-white, had higher anxiety sensitivity, and higher overall phobic avoidance at baseline were less likely to show clinical improvement at 12 months. A greater understanding of these predictors may help clinicians identify who is at greatest risk for persistent panic-related symptoms and to plan the intensity of interventions accordingly.

Author information

Author/s: Chavira, Denise A (DA); Stein, Murray B (MB); Golinelli, Daniela (D); Sherbourne, Cathy D (CD); Craske, Michelle G (MG); Sullivan, Greer (G); Bystritsky, Alexander (A); Roy-Byrne, Peter P (PP);

Affiliation: Department of Psychiatry, University of California, San Diego, CA 92037, USA. dchavira(-atsign-)ucsd.edu

Grants: MH065324 (Agency:NIMH NIH HHS) ; MH072952 (Agency:NIMH NIH HHS) ; MH57835 (Agency:NIMH NIH HHS) ; MH57858 (Agency:NIMH NIH HHS) ; MH58915-03 (Agency:NIMH NIH HHS) ; MH64122 (Agency:NIMH NIH HHS)

Journal and publication information

Publication Type: Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, N.I.H., Extramural

Journal: The Journal of nervous and mental disease (J Nerv Ment Dis), published in United States. (Language: eng)

Reference: 2009-Oct; vol 197 (issue 10) : pp 715-21

Dates: Created 2009/10/15; Completed 2009/10/29;

PMID: 19829198, status: MEDLINE (last retrieval date: 10/29/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adolescent Adult Aged Anti-Anxiety Agents - therapeutic use Cognitive Therapy - methods Combined Modality Therapy Comorbidity Female Follow-Up Studies Humans Logistic Models

Logistic Models Male Middle Aged Panic Disorder - diagnosis; epidemiology; therapy Personality Assessment Phobic Disorders - epidemiology Primary Health Care Probability Psychiatric Status Rating Scales Severity of Illness Index Treatment Outcome

Associated Chemicals: Anti-Anxiety Agents (0)

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