Association of polymorphisms in regulatory regions of interleukin-12p40 gene and cytokine serum level with colorectal cancer.

Full Abstract

The present study investigates the association between IL12Bpro and +16974A/C in 3' -untranslated region (UTR) polymorphisms of IL12B and IL-12p40 serum level related to development of colorectal cancer (CRC). Our results showed similar distribution of both the investigated polymorphisms among CRC patients and healthy donors, which suggests that these polymorphisms in IL12B were not associated with the development of CRC. However, we found an increased IL-12p40 level in sera from patients compared to healthy donors and the highest level was observed in stage I compared to more advanced stages of CRC. These findings demonstrated that IL-12p40 serum level has an association with the progression of CRC.

Author information

Author/s: Miteva, L (L); Stanilov, N (N); Deliysky, T (T); Mintchev, N (N); Stanilova, S (S);

Affiliation: Department of Molecular Biology, Immunology and Genetics, Faculty of Medicine, Trakia University, Stara Zagora, Bulgaria.

Journal and publication information

Publication Type: Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't

Journal: Cancer investigation (Cancer Invest), published in England. (Language: eng)

Reference: 2009-Nov; vol 27 (issue 9) : pp 924-31

Dates: Created 2009/10/16; Completed 2009/10/29;

PMID: 19832040, status: MEDLINE (last retrieval date: 10/29/2009, IMS Date: )

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