Research article summary (published 30 Oct 2009):

Phase II trial of thalidomide, irinotecan and gemcitabine in chemonaive patients with advanced non-small cell lung cancer.

Full Abstract

This study aim was to determine the efficacy and safety of the combination of Gemcitabine 1000 mg/m(2) day 1 & 8 and Irinotecan 100 mg/m(2) day 1 & 8 with escalating dose of thalidomide in chemonaive patients with advanced non-small cell lung cancer. Among the 20 patients who met eligibility criteria and received treatment, two patients (10%) experienced partial response and 14 (70%) experienced stable disease. The median time to disease progression was 4 months (95% CI: 2.8-6.6). The 1 year and 2 year survival rates were 36% and 27%, respectively. This combination is active in advanced NSCLC with manageable toxicity profile.

Author information

Author/s: Jazieh, A R (AR); Komrokji, R (R); Gupta, A (A); Patil, S (S); Flora, D (D); Knapp, M (M); Issa, M (M); Abdel Karim, N (N);

Affiliation: University of Cincinnati, Cincinnati, OH, USA. jazieha(-atsign-)ngha.med.sa

Journal and publication information

Publication Type: Clinical Trial, Phase II; Journal Article

Journal: Cancer investigation (Cancer Invest), published in England. (Language: eng)

Reference: 2009-Nov; vol 27 (issue 9) : pp 932-6

Dates: Created 2009/10/16; Completed 2009/10/29;

PMID: 19832041, status: MEDLINE (last retrieval date: 10/29/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adult Aged Antineoplastic Combined Chemotherapy Protocols - adverse effects; therapeutic use Camptothecin - administration & dosage; analogs & derivatives Carcinoma, Non-Small-Cell Lung - drug therapy; mortality; pathology Deoxycytidine - administration & dosage; analogs & derivatives Female Humans

Kaplan-Meiers Estimate Lung Neoplasms - drug therapy; mortality; pathology Male Middle Aged Neoplasm Staging Thalidomide - administration & dosage Time Factors Treatment Outcome

Associated Chemicals: irinotecan (100286-90-6) ; gemcitabine (103882-84-4) ; Thalidomide (50-35-1) ; Camptothecin (7689-03-4) ; Deoxycytidine (951-77-9)

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