Vitamin D and non-Hodgkin lymphoma risk in adults: a review.

Full Abstract

Animal and human studies support a protective effect of vitamin D sufficiency related to malignancy by uncovering paracrine and autocrine effects of extra-renal 25-hydroxyvitamin D (25(OH)D) activation including regulation of cell cycle proliferation, apoptosis induction, and increased cell differentiation signaling. Recent epidemiologic studies demonstrate a reduction in non-Hodgkin lymphoma (NHL) risk with increased sunlight exposure. As sunlight is a major vitamin D source, it has been suggested that vitamin D status may mediate this observed association. This review provides a comprehensive discussion of the current epidemiologic evidence with regard to the investigation of an association between vitamin D status and NHL risk.

Author information

Author/s: Kelly, Jennifer L (JL); Friedberg, Jonathan W (JW); Calvi, Laura M (LM); van Wijngaarden, Edwin (E); Fisher, Susan G (SG);

Affiliation: Department of Community and Preventive Medicine, University of Rochester, Rochester, NY 14642, USA. jennifer_kelly(-atsign-)urmc.rochester.edu

Grants: P50 CA130805 (Agency:NCI NIH HHS) ; T32 HL007152 (Agency:NHLBI NIH HHS) ; UL1 RR024160 (Agency:NCRR NIH HHS)

Journal and publication information

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review

Journal: Cancer investigation (Cancer Invest), published in England. (Language: eng)

Reference: 2009-Nov; vol 27 (issue 9) : pp 942-51

Dates: Created 2009/10/16; Completed 2009/10/29;

PMID: 19832043, status: MEDLINE (last retrieval date: 10/29/2009, IMS Date: )

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