Research article summary (published 14 Oct 2009):

Fast synaptic subcortical control of hippocampal circuits.

Full Abstract

Cortical information processing is under state-dependent control of subcortical neuromodulatory systems. Although this modulatory effect is thought to be mediated mainly by slow nonsynaptic metabotropic receptors, other mechanisms, such as direct synaptic transmission, are possible. Yet, it is currently unknown if any such form of subcortical control exists. Here, we present direct evidence of a strong, spatiotemporally precise excitatory input from an ascending neuromodulatory center. Selective stimulation of serotonergic median raphe neurons produced a rapid activation of hippocampal interneurons. At the network level, this subcortical drive was manifested as a pattern of effective disynaptic GABAergic inhibition that spread throughout the circuit. This form of subcortical network regulation should be incorporated into current concepts of normal and pathological cortical function.

Author information

Author/s: Varga, Viktor (V); Losonczy, Attila (A); Zemelman, Boris V (BV); Borhegyi, Zsolt (Z); Nyiri, Gábor (G); Domonkos, Andor (A); Hangya, Balázs (B); Holderith, Noémi (N); Magee, Jeffrey C (JC); Freund, Tamás F (TF);

Affiliation: Institute of Experimental Medicine, Budapest 1083, Hungary. vargav(-atsign-)koki.hu

Grants: HHMI55005608 (Agency:Howard Hughes Medical Institute) ; MH-54671 (Agency:NIMH NIH HHS)

Journal and publication information

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal: Science (New York, N.Y.) (Science), published in United States. (Language: eng)

Reference: 2009-Oct; vol 326 (issue 5951) : pp 449-53

Dates: Created 2009/10/16; Completed 2009/10/26;

PMID: 19833972, status: MEDLINE (last retrieval date: 10/26/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Animals Electric Stimulation Excitatory Postsynaptic Potentials Glutamic Acid - physiology Hippocampus - cytology; physiology Inhibitory Postsynaptic Potentials Interneurons - physiology Mice Neural Inhibition - physiology Neural Pathways - physiology

Neural Pathways - physiology Neurons, Afferent - physiology Patch-Clamp Techniques Photic Stimulation Raphe Nuclei - cytology; physiology Rats Rats, Sprague-Dawley Serotonin - physiology Synapses - physiology Synaptic Potentials - physiology

Associated Chemicals: Serotonin (50-67-9) ; Glutamic Acid (56-86-0)

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