Structure casts light on mtDNA replication.

Full Abstract

In this issue, Lee et al. (2009) present a crystal structure of the human mitochondrial DNA polymerase (POLgamma). The structure of this heterotrimeric enzyme lays a foundation for understanding how POLgamma mutations cause human mitochondrial disease and why some antiviral nucleoside analogs cause cellular toxicity.

Author information

Author/s: Falkenberg, Maria (M); Larsson, Nils-Göran (NG);

Affiliation: Department of Medical Biochemistry and Cell Biology, Göteborg University, SE-405 30 Göteborg, Sweden. maria.falkenberg(-atsign-)medkem.gu.se

Journal and publication information

Publication Type: Comment; Journal Article; Research Support, Non-U.S. Gov't

Journal: Cell (Cell), published in United States. (Language: eng)

Reference: 2009-Oct; vol 139 (issue 2) : pp 231-3

Dates: Created 2009/10/19; Completed 2009/11/13;

PMID: 19837028, status: MEDLINE (last retrieved date: 11/15/2009)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

Comments and Corrections

CommentOn: Cell. 2009 Oct 16;139(2):312-24. (PMID: 19837034)

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