Research article summary (published 30 Oct 2009):

The gut feeling of Treg cells: IL-10 is the silver lining during colitis.

Full Abstract

Regulatory T cells that express the transcription factor Foxp3 are pivotal in suppressing autoimmune responses. A report in this issue describes a key role for interleukin 10 produced by lamina propria macrophages in maintaining Foxp3 expression during inflammatory responses in the intestine.

Author information

Author/s: Unutmaz, Derya (D); Pulendran, Bali (B);

Journal and publication information

Publication Type: Comment; News

Journal: Nature immunology (Nat Immunol), published in United States. (Language: eng)

Reference: 2009-Nov; vol 10 (issue 11) : pp 1141-3

Dates: Created 2009/10/20; Completed 2009/10/23;

PMID: 19841645, status: MEDLINE (last retrieval date: 10/23/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

Comments and Corrections

CommentOn: Nat Immunol. 2009 Nov;10(11):1178-84. (PMID: 19783988)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Animals Colitis - immunology Forkhead Transcription Factors - immunology Interleukin-10 - immunology Intestines - immunology

Intestines - immunology Macrophages - immunology Mice Mucous Membrane - immunology T-Lymphocytes, Regulatory - immunology

Associated Chemicals: Forkhead Transcription Factors (0) ; Foxp3 protein, mouse (0) ; Interleukin-10 (130068-27-8)

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