A coming-of-age story: activation-induced cytidine deaminase turns 10.

Full Abstract

The discovery and characterization of activation-induced cytidine deaminase (AID) 10 years ago provided the basis for a mechanistic understanding of secondary antibody diversification and the subsequent generation and maintenance of cellular memory in B lymphocytes, which signified a major advance in the field of B cell immunology. Here we celebrate and review the triumphs in the mission to understand the mechanisms through which AID influences antibody diversification, as well as the implications of AID function on human physiology. We also take time to point out important ongoing controversies and outstanding questions in the field and highlight key experiments and techniques that hold the potential to elucidate the remaining mysteries surrounding this vital protein.

Author information

Author/s: Delker, Rebecca K (RK); Fugmann, Sebastian D (SD); Papavasiliou, F Nina (FN);

Affiliation: Laboratory of Lymphocyte Biology, Rockefeller University, New York, New York, USA.

Grants: CA098495 (Agency:NCI NIH HHS)

Journal and publication information

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, U.S. Gov't, Non-P.H.S.; Review

Journal: Nature immunology (Nat Immunol), published in United States. (Language: eng)

Reference: 2009-Nov; vol 10 (issue 11) : pp 1147-53

Dates: Created 2009/10/20; Completed 2009/10/23;

PMID: 19841648, status: MEDLINE (last retrieval date: 10/23/2009, IMS Date: )

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