Increase in quality, but not quantity, of clinical trials in acute pain: 1992 versus 2007.

Full Abstract

The annual number of published clinical trials in acute postoperative pain in adults has changed little in 15 yr and, as a fraction of all clinical trials published in the six highest impact journals in anesthesiology, has actually decreased from 16% (95% confidence interval: 12-20) to 11% (95% confidence interval: 9-15). However, the methodological quality of reports has improved, with explicit statements on power analysis, allocation concealment, and specification of primary end points exceeding 90% of reports in 2007. There has been a shift in hypothesis interests away from neuraxial analgesia and toward multimodal analgesia.

Author information

Author/s: Reeves, Mark D (MD);

Affiliation: Department of Anaesthesia, North West Regional Hospital, Burnie, Tasmania, Australia. mark.reeves(-atsign-)dhhs.tas.gov.a

Journal and publication information

Publication Type: Comparative Study; Journal Article

Journal: Anesthesia and analgesia (Anesth Analg), published in United States. (Language: eng)

Reference: 2009-Nov; vol 109 (issue 5) : pp 1656-8

Dates: Created 2009/10/21; Completed 2009/11/05;

PMID: 19843804, status: MEDLINE (last retrieval date: 11/5/2009, IMS Date: )

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