Challenges in developing evidence-based drug dosing guidelines for adults and children receiving renal replacement therapy.

Full Abstract

The challenges of appropriate drug dosing in patients with renal failure requiring renal replacement therapy (RRT) have been exacerbated by recent trends in both RRT technology and practices. Nearly all these changes have resulted in augmented drug clearance, making most existing RRT drug dosing recommendations obsolete. Many barriers exist to conducting research to update our knowledge of appropriate drug dosing in the context of contemporary RRT. Recommendations on how this research could be conducted, including the use of in vitro techniques, are offered here.

Author information

Author/s: Mueller, B A (BA); Smoyer, W E (WE);

Affiliation: Department of Clinical, Social, and Administrative Sciences, College of Pharmacy, University of Michigan, Ann Arbor, Michigan, USA.

Journal and publication information

Publication Type: Journal Article

Journal: Clinical pharmacology and therapeutics (Clin Pharmacol Ther), published in United States. (Language: eng)

Reference: 2009-Nov; vol 86 (issue 5) : pp 479-82

Dates: Created 2009/10/21; Completed 2009/11/04;

PMID: 19844225, status: MEDLINE (last retrieval date: 11/4/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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