The neuronal control of hypoxic ventilation: erythropoietin and sexual dimorphism.

Full Abstract

Using mice, we demonstrated that when oxygen supply is lowered, erythropoietin (Epo), the main regulator of red blood cell production, modulates the ventilatory response by interacting with central (brainstem) and peripheral (carotid bodies) respiratory centers. We showed that enhanced Epo levels in the brainstem increased the hypoxic ventilatory response, and that intracerebroventricular injection of an Epo antagonist (soluble Epo receptor) abolished the ventilatory acclimatization to hypoxia. More recently, we have found that the impact of Epo on ventilation occurs in a sex-dependent manner. Keeping in mind that women are less susceptible to several respiratory sicknesses and syndromes than men, we suggest that Epo plays a key role in sexually-dimorphic hypoxic ventilation. Accordingly, we foresee that Epo has a potential therapeutic use as treatment for hypoxia-associated ventilatory diseases.

Author information

Author/s: Gassmann, Max (M); Tissot van Patot, Martha (M); Soliz, Jorge (J);

Affiliation: Institute of Veterinary Physiology, University of Zurich, Zurich, Switzerland. maxg(-atsign-)access.uzh.ch

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Review

Journal: Annals of the New York Academy of Sciences (Ann N Y Acad Sci), published in United States. (Language: eng)

Reference: 2009-Oct; vol 1177 (issue ) : pp 151-61

Dates: Created 2009/10/22; Completed 2009/11/02;

PMID: 19845617, status: MEDLINE (last retrieval date: 11/2/2009, IMS Date: )

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