A single-center dose-comparison study of botulinum neurotoxin type A in females with upper facial rhytids: assessing patients' perception of treatment outcomes.

Full Abstract

BACKGROUND: Few studies evaluate patient-reported outcomes (PROs). OBJECTIVES: To assess the PROs of treatment with botulinum neurotoxin type A (BoNTA) in upper facial lines; to evaluate two new PRO instruments. METHODS: Prospective, randomized, double-blind study of 32 U, 64 U, or 96 U BoNTA divided among 16 sites. Measurements included the Facial Line Outcomes (FLO-11) Questionnaire version 1.0 and the Self-Perception of Age (SPA) measure version 2.0. RESULTS: Sixty females, mean age 42 +/- 8.7 years, were enrolled. Significant improvements (P<0.01) in mean FLO-11 scores occurred by week 2 for all groups and remained significant through week 16 for all groups except the 32-U group. Approximately 45-60% of the patients reported looking younger by a mean of 3.6-5.8 years. Conclusion: BoNTA treatment resulted in desired relaxed and younger appearance, as measured by the FLO-11 Questionnaire and the SPA measure.

Author information

Author/s: Carruthers, Alastair (A); Carruthers, Jean (J);

Affiliation: University of British Columbia, Department of Dermatology and Skin Science, Vancouver, BC, Canada. alastair(-atsign-)carruthers.net

Journal and publication information

Publication Type: Journal Article; Randomized Controlled Trial

Journal: Journal of drugs in dermatology : JDD (J Drugs Dermatol), published in United States. (Language: eng)

Reference: 2009-Oct; vol 8 (issue 10) : pp 924-9

Dates: Created 2009/10/26; Completed 2009/11/05;

PMID: 19852121, status: MEDLINE (last retrieval date: 11/5/2009, IMS Date: )

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