Research article summary (published 21 Oct 2009):

Suggestive linkage detected for blood pressure related traits on 2q and 22q in the population on the Samoan islands.

Full Abstract

BACKGROUND: High blood pressure or hypertension is a major risk factor involved in the development of cardiovascular diseases. We conducted genome-wide variance component linkage analyses to search for loci influencing five blood pressure related traits including the quantitative traits systolic blood pressure (SBP), diastolic blood pressure (DBP) and pulse pressure (PP), the dichotomous trait hypertension (HT) and the bivariate quantitative trait SBP-DBP in families residing in American Samoa and Samoa, as well as in the combined sample from the two polities. We adjusted the traits for a number of environmental covariates such as smoking, alcohol consumption, physical activity and material life style. RESULTS: We found suggestive univariate linkage for SBP on chromosome 2q35-q37 (LOD 2.4) and for PP on chromosome 22q13 (LOD 2.2), two chromosomal regions that recently have been associated with SBP and PP, respectively. CONCLUSION: We have detected additional evidence for a recently reported locus associated with SBP on chromosome 2q and a susceptibility locus for PP on chromosome 22q. However, differences observed between the results from our three partly overlapping genetically homogenous study samples from the Samoan islands suggest that additional studies should be performed in order to verify these results.

Author information

Author/s: Aberg, Karolina (K); Dai, Feng (F); Viali, Satupaitea (S); Tuitele, John (J); Sun, Guangyun (G); Indugula, Subba R (SR); Deka, Ranjan (R); Weeks, Daniel E (DE); McGarvey, Stephen T (ST);

Affiliation: Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, 130 Desoto St, Pittsburgh, PA 15261, USA. kaaberg(-atsign-)vcu.edu

Grants: R01-DK59642 (Agency:NIDDK NIH HHS)

Journal and publication information

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal: BMC medical genetics (BMC Med Genet), published in England. (Language: eng)

Reference: 2009-; vol 10 (issue ) : pp 107

Dates: Created 2009/10/29; Completed 2009/10/30; Revised 2009/10/30;

PMID: 19852796, status: MEDLINE (last retrieval date: 11/2/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adult Blood Pressure - genetics Chromosomes, Human, Pair 2 Chromosomes, Human, Pair 22 Female Genetic Predisposition to Disease Humans

Humans Hypertension - genetics Linkage (Genetics) Male Middle Aged Phenotype Samoa

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