A novel tetradecapeptide isolated from bovine adrenal medulla chromaffin vesicles with strong homology to an internal sequence coded by the rat 1B1075 (Preprosecretogranin III) gene.

Full Abstract

A novel tetradecapeptide, PheProLysProAlaGlySerGlnAspLysProLeuHisAsn, was isolated from boiling water extracts of bovine adrenal medulla chromaffin vesicles. The primary structure of the peptide was characterized by amino acid analysis, fast atom bombardment mass spectrometry, and gas-phase sequencing. The synthetic and native peptides comigrated on reversed-phase high-performance liquid chromatography, supporting the proposed sequence. This peptide shares 86% homology to residues 67-80 of the recently reported rat 1B1075 gene product secretogranin III and probably represents a processed product derived from the bovine equivalent.

Author information

Author/s: Sigafoos, J (J); Merrill, B M (BM); Taylor, L (L); Diliberto, E J (EJ); Viveros, O H (OH);

Affiliation: Division of Pharmacology, The Wellcome Research Laboratories, 3030 Cornwallis Road, Research Triangle Park, North Carolina 27709, USA.

Journal and publication information

Publication Type: Journal Article

Journal: Molecular and cellular neurosciences (Mol Cell Neurosci), published in United States. (Language: eng)

Reference: 1991-Dec; vol 2 (issue 6) : pp 511-6

Dates: Created 2009/11/16;

PMID: 19912836, status: In-Data-Review (last retrieved date: 11/16/2009)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

External Links for this article
(including full text providers, if available):

Click Electronic Full-text Provider Links to see options for finding the electronic full text links to this article. Note there may be a subscription or fee required for access to the full text. See our FAQ for information on finding FREE full text articles.

This article may also be located in paper journal collections available in many libraries. Use the Journal and Publication Information above to find the full article.

MeSH headings (categories)

This article was linked to the MeSH Headings (categories) shown below.

No MeSH Headings found.

The article may not be MeSH Indexed as yet.

Note: Bold headings indicate primary MeSH headings or qualifiers.

This article has not been indexed for related articles as yet, however you can still use the live related article search links below.

See 100+ related articles.

See a larger map of 100+ related articles.