Randomized clinical trials in esophageal carcinoma.

Full Abstract

The treatment of esophageal cancer with curative intent remains highly controversial, with advocates of surgery alone, chemoradiotherapy alone, surgery with adjuvant therapy (including neoadjuvant and postoperative), and trimodality therapy each contributing prospective randomized controlled trials (PRCTs) to the body of scientific publications between 2000 and 2008. Any improvements in survival have been small in absolute percentage terms, and as such PRCTs published over the last decade have met the same primary obstacle encountered by the studies from the two prior decades, namely lack of power to detect small differences in outcome. Variations in staging methods, surgical technique, radiotherapy technique, and chemotherapy regime have in turn been the subject of PRCTs over the last nine years. In many cases primary end points have not been survival but rather rates of complication or response. As well as giving an overview of PRCTs, this article collates the level Ia evidence published to date.

Author information

Author/s: Barnett, Stephen A (SA); Rizk, Nabil P (NP);

Affiliation: Department of Surgery, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA.

Journal and publication information

Publication Type: Journal Article

Journal: Surgical oncology clinics of North America (Surg Oncol Clin N Am), published in United States. (Language: eng)

Reference: 2010-Jan; vol 19 (issue 1) : pp 59-80

Dates: Created 2009/11/16;

PMID: 19914560, status: In-Process (last retrieved date: 11/17/2009)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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