Research article summary (published 30 Dec 1990):

Alterations of central norepinephrine, dopamine and serotonin in several strains of mice following acute stressor exposure.

Full Abstract

Exposure to inescapable footshock provoked region-specific alterations of norepinephrine (NE), dopamine (DA) and serotonin (5-HT) activity across six strains of mice (A/J, BALB/cByJ, C3H/HeJ, C57BL/6J, DBA/2J and CD-1). The stressor provoked reductions of hypothalamic NE and increased MHPG accumulation in all strains. In contrast, the effects of the stressor on NE activity in the hippocampus and locus coeruleus varied appreciably across strains. In the mesocortex and nucleus accumbens shock induced an increase of DOPAC accumulation and pronounced reductions of DA in some strains, while in others these variations were less pronounced or entirely absent. Stressor-provoked alterations of 5-HT and 5-HIAA were most evident in the mesocortex. Strain-specific neurochemical alterations following footshock are discussed relative to stressor-induced behavioral disturbances and animal models of depression.

Author information

Author/s: Shanks, N (N); Zalcman, S (S); Zacharko, R M (RM); Anisman, H (H);

Affiliation: Department of Psychology, Carleton University, Ottawa, Ontario.

Journal and publication information

Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

Journal: Pharmacology, biochemistry, and behavior (Pharmacol Biochem Behav), published in UNITED STATES. (Language: eng)

Reference: 1991-Jan; vol 38 (issue 1) : pp 69-75

Dates: Created 1991/05/23; Completed 1991/05/23; Revised 2006/11/15;

PMID: 2017456, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Animals Biogenic Amines - metabolism Brain Chemistry - physiology Chromatography, High Pressure Liquid Dopamine - metabolism Mice Mice, Inbred A Mice, Inbred BALB C

Mice, Inbred BALB C Mice, Inbred C3H Mice, Inbred C57BL Mice, Inbred DBA Norepinephrine - metabolism Serotonin - metabolism Species Specificity Stress, Psychological - metabolism

Associated Chemicals: Biogenic Amines (0) ; Serotonin (50-67-9) ; Norepinephrine (51-41-2) ; Dopamine (51-61-6)

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