Research article summary (published 29 Sep 1990):

Possible influence of carbamazepine on plasma imipramine concentrations in children with attention deficit hyperactivity disorder.

Full Abstract

The effect of carbamazepine on the plasma concentration of imipramine and its metabolite desipramine was examined retrospectively in 36 sex- and age-matched children with attention deficit hyperactivity disorder. One-half of the children received imipramine and the other half received combined carbamazepine and imipramine for 1-6 months. The imipramine dosage was significantly higher in the combined treatment group than in the imipramine-only group. Despite receiving larger doses, the combined treatment group had significantly lower mean levels of imipramine, desipramine, and total tricyclic antidepressant compared with those children receiving imipramine alone. Lowered plasma concentrations of tricyclic antidepressants with carbamazepine coadministration have not been reported previously. Although more rigorous studies are needed to confirm these findings, our data suggest that increased imipramine doses may be necessary for adequate response in children on combined therapy. Moreover, toxicity could result upon withdrawal without imipramine dosage adjustment.

Author information

Author/s: Brown, C S (CS); Wells, B G (BG); Cold, J A (JA); Froemming, J H (JH); Self, T H (TH); Jabbour, J T (JT);

Affiliation: Department of Clinical Pharmacy, University of Tennessee, Memphis 38163.

Journal and publication information

Publication Type: Clinical Trial; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

Journal: Journal of clinical psychopharmacology (J Clin Psychopharmacol), published in UNITED STATES. (Language: eng)

Reference: 1990-Oct; vol 10 (issue 5) : pp 359-62

Dates: Created 1991/01/28; Completed 1991/01/28; Revised 2006/11/15;

PMID: 2258453, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

Comments and Corrections

CommentIn: J Clin Psychopharmacol. 1992 Feb;12(1):67-8. (PMID: 1552043)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adolescent Attention Deficit Disorder with Hyperactivity - blood; drug therapy; psychology Carbamazepine - administration & dosage; adverse effects; pharmacokinetics Child Child, Preschool Desipramine - pharmacokinetics Drug Interactions

Drug Interactions Drug Therapy, Combination Female Humans Imipramine - administration & dosage; adverse effects; pharmacokinetics Male Retrospective Studies

Associated Chemicals: Carbamazepine (298-46-4) ; Desipramine (50-47-5) ; Imipramine (50-49-7)

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