Research article summary (published 30 Oct 1987):

Biochemical and behavioural studies on indole-pyruvic acid: a keto-analogue of tryptophan.

Full Abstract

The effects of acute or repeated administration of indole-pyruvic acid (IPA), a keto-analogue of tryptophan (TRP), were studied in various brain areas of rats by measuring the changes of 5-hydroxytryptamine (5-HT) and of norepinephrine (NE) content and metabolism. The analgesic and sedative properties of the molecule were evaluated by measuring the tail-flick latency, the spontaneous activity and the potentiation of the barbiturate-induced sleep. Acute or repeated administrations of IPA (20 or 50 mg/kg) increased the utilization of 5-HT in the cortex, hippocampus, diencephalon and brain-stem of rats fed a standard laboratory diet. IPA, however, did not substitute TRP in rats fed a TRP-free diet. The administration of this keto-analogue resulted also in a decreased content of 3-methoxy-4-hydroxy-phenylglycol (MHPG) in the cortex and in the brain-stem, thus suggesting a decreased utilization of NE in these areas. Furthermore, IPA administration decreased the rats' spontaneous activity, increased the duration of barbiturate-induced sleep and increased the tail-flick time, thus indicating that it has sedative and analgesic properties.

Author information

Author/s: Bacciottini, L (L); Pellegrini-Giampietro, D E (DE); Bongianni, F (F); de Luca, G (G); Beni, M (M); Politi, V (V); Moroni, F (F);

Affiliation: Department of Pharmacology, University of Florence, Firenze, Italy.

Journal and publication information

Publication Type: Journal Article

Journal: Pharmacological research communications (Pharmacol Res Commun), published in UNITED STATES. (Language: eng)

Reference: 1987-Nov; vol 19 (issue 11) : pp 803-17

Dates: Created 1988/04/25; Completed 1988/04/25; Revised 2003/11/14;

PMID: 2451257, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: 18 Feb 2009 00:00:00)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Animals Behavior, Animal - drug effects Brain Chemistry - drug effects Hydroxyindoleacetic Acid - metabolism Indoles - pharmacology Male

Methoxyhydroxyphenylglycol - metabolism Motor Activity - drug effects Norepinephrine - metabolism Rats Rats, Inbred Strains Serotonin - metabolism

Associated Chemicals: Indoles (0) ; indol-3-yl pyruvic acid (392-12-1) ; Serotonin (50-67-9) ; Norepinephrine (51-41-2) ; Methoxyhydroxyphenylglycol (534-82-7) ; Hydroxyindoleacetic Acid (54-16-0)

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