Granulocyte migration ability in subjects hypersensitive to aspirin.

Full Abstract

The reported study was carried out on 32 patients with atopic asthma. Twenty-seven patients had atopic asthma and were hypersensitive to aspirin. Twenty patients were hypersensitive only to aspirin. At the time of the investigation the patients were in the remission period at the beginning of the investigations and the lowest aspirin dose producing hypersensitivity symptoms was established in each case. It ranged from 0.05 to 0.5 g. In the group of patients hypersensitive to aspirin were included those in whom spirometric measurements demonstrated a FEV1 fall below 20% of the initial level. In all the patients and controls studied the "in vitro" granulocyte migration test was done by Clausen's method and "in vivo" by Southam's method. As shown in the presented results, patients with aspirin hypersensitivity have a defect in the migration of granulocytes of the vascular and tissue pools.

Author information

Author/s: Matusiewicz, R (R); Lebiedowski, K (K); Czajkowski, M (M); Wacek, W (W);

Affiliation: I Department of Internal Diseases. Grochow Hospital, Warsaw, Poland.

Journal and publication information

Publication Type: Comparative Study; Journal Article

Journal: Allergologia et immunopathologia (Allergol Immunopathol (Madr)), published in SPAIN. (Language: eng)

Reference: -1989 Sep-Oct; vol 17 (issue 5) : pp 241-4

Dates: Created 1990/02/15; Completed 1990/02/15; Revised 2006/11/15;

PMID: 2610186, status: MEDLINE (last retrieved date: 2/18/2009)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

External Links for this article
(including full text providers, if available):

Click Electronic Full-text Provider Links to see options for finding the electronic full text links to this article. Note there may be a subscription or fee required for access to the full text. See our FAQ for information on finding FREE full text articles.

This article may also be located in paper journal collections available in many libraries. Use the Journal and Publication Information above to find the full article.