CNS mechanisms of pain and analgesia.

Full Abstract

This paper reviews briefly the spinal and supraspinal elements by which high threshold stimuli gain access to various levels of the neuraxis. Emphasis is also placed on the fact that transmission through each link is subject to an ongoing modulation. Several probable levels of modulation are discussed. The pharmacology of systems which may modulate the encoding process, such as opioids and monoamines, are also considered.

Author information

Author/s: Yaksh, T L (TL);

Affiliation: Department of Neurosurgical Research, Mayo Clinic, Rochester, Minnesota 55905.

Journal and publication information

Publication Type: Journal Article; Review

Journal: Cancer surveys (Cancer Surv), published in ENGLAND. (Language: eng)

Reference: 1988-; vol 7 (issue 1) : pp 5-28

Dates: Created 1988/07/29; Completed 1988/07/29; Revised 2004/11/17;

PMID: 2838170, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: 18 Feb 2009 00:00:00)

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