Research article summary (published 30 Mar 1988):

[Effect of M and N-cholinoblockers on the excitability of the dorsal hippocampus in acute alcoholic intoxication]

(Vliianie M- i N-kholinoblokatorov na vozbudimost' dorsal'nogo gippokampa v usloviiakh ostroi alkogol'noi intoksikatsii.)

Full Abstract

It has been established in chronic experiments on rabbits that acute alcohol intoxication increased the after-discharge thresholds in response to electrical stimulation of dorsal hippocampus. It has been shown that neurotropic agents selectively blocking M- or N-cholinoceptors exerted various effects. M-cholino-blocker methamizol (1 mg/kg, i. p.) decreased the excitability of dorsal hippocampus, potentiated EEG and behavioural effects of alcohol intoxication. N-cholinoblocker etherophen (IEM-506, 20 mg/kg, i. p.), on the contrary, increased the excitability of dorsal hippocampus and reduced behavioural effects of alcohol administration.

Author information

Author/s: Tkachenko, E I (EI);

Journal and publication information

Publication Type: English Abstract; Journal Article

Journal: Biulleten' eksperimental'noi biologii i meditsiny (Biull Eksp Biol Med), published in USSR. (Language: rus)

Reference: 1988-Apr; vol 105 (issue 4) : pp 434-5

Dates: Created 1988/06/07; Completed 1988/06/07; Revised 2008/10/08;

PMID: 2896023, status: MEDLINE (last retrieved date: 2/18/2009)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MeSH Headings (categories) shown below.

Alcoholic Intoxication - physiopathology Animals Benactyzine - analogs & derivatives; pharmacology Diphenylacetic Acids - analogs & derivatives; pharmacology Electric Stimulation

Electric Stimulation Hippocampus - drug effects; physiopathology Parasympatholytics - pharmacology Rabbits Sympatholytics - pharmacology

Note: Bold headings indicate primary MeSH headings or qualifiers.

Associated Chemicals: Diphenylacetic Acids (0) ; Parasympatholytics (0) ; Sympatholytics (0) ; ethyldiphacil (13426-07-8) ; Benactyzine (302-40-9) ; metamizil (57-36-3)

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