Research article summary (published 30 Dec 1977):

[Morphine analgesia: neurobiologic data]

(L'analgésie morphinique: données neurobiologiques.)

Full Abstract

Recent Neurobiological (Neurophysiological, Histochemical, Neurochemical and behavioural studies) data have indicated that the analgesic effects of morphine may, at least in part, be explained by two modes of action. A--Morphine has a direct depressive action at a spinal level on the activity of neurones of the grey matter of the dorsal horn which run towards the higher centres of the encephalon. These effects are exerted preferentially on activities induced by the activity of fine non-myelinized fibres (C). These mechanisms are discussed taking into account recent data concerning polypeptides (substance P and encephalins). B--Morphine acts at the level of the brain stem (periaqueductal grey matter, raphian nucleus, etc.) reinforcing the activity of descending bulbo-spinal pathways which block the transmission of painful messages within the cord.

Author information

Author/s: Besson, J M (JM); Le Bars, D (D); Oliveras, J L (JL);

Journal and publication information

Publication Type: Comparative Study; English Abstract; Journal Article; Review

Journal: Annales de l'anesthésiologie française (Ann Anesthesiol Fr), published in FRANCE. (Language: fre)

Reference: 1978-; vol 19 (issue 5) : pp 343-69

Dates: Created 1978/11/29; Completed 1978/11/29; Revised 2006/11/15;

PMID: 29530, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Analgesia Animals Axons - physiology Brain Stem - drug effects; physiology Cats Depression, Chemical Electric Stimulation Electronarcosis Enkephalins - pharmacology Morphine - pharmacology

Morphine - pharmacology Naloxone - pharmacology Neurons - drug effects; physiology Rats Receptors, Opioid - drug effects Serotonin - metabolism Spinal Cord - drug effects Substance P - antagonists & inhibitors Substantia Gelatinosa - drug effects Synaptic Transmission - drug effects

Associated Chemicals: Enkephalins (0) ; Receptors, Opioid (0) ; Substance P (33507-63-0) ; Naloxone (465-65-6) ; Serotonin (50-67-9) ; Morphine (57-27-2)

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