Research article summary (published 29 Sep 1977):

Early first-trimester abortion induction by Silastic vaginal devices for continuous release of 15(S)=15-methyl prostaglandin F2alpha methyl ester.

Full Abstract

The abortifacient efficacy of four Silastic devices containing 15(S)-15-methyl prostaglandin F2alpha methyl ester (15-Me-PGF2alpha methyl ester) was evaluated by single vaginal insertion and retention for 24 hours in four groups of ten patients each at 31 to 49 days beyond the 1st day of the last menstrual period. There were eight complete and two incomplete abortions in the group receiving a device with a drug concentration of 0.5% and a surface area of 20 sq cm. Four complete abortions, four incomplete abortions, and two failures occurred with a 0.2%, 10 sq cm device. Seven complete and two incomplete abortions were obtained with a 0.5%, 10 dq cm device; one patient in this group was found to have aborted prior to treatment. A 0.5%, 2o sq cm device with one-half the thickness of the other 0.5% devices yielded five complete abortions, one incomplete abortion, and four failures. Side effects were minor and well tolerated in each group. Serial determinations of plasma progesterone, human chorionic gonadotropin, and 15-Me-PGF2alpha were obtained and related to the outcome of therapy. Because of failure to achieve sustained blood levels of drug or satisfactory rates of complete abortions, this technique, with the devices used in this study, is not believed to be acceptable for routine early first-trimester pregnancy termination.

Author information

Author/s: Robins, J (J);

Journal and publication information

Publication Type: Journal Article

Journal: Fertility and sterility (Fertil Steril), published in UNITED STATES. (Language: eng)

Reference: 1977-Oct; vol 28 (issue 10) : pp 1048-55

Dates: Created 1977/11/30; Completed 1977/11/30; Revised 2004/11/17;

PMID: 561712, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Abortion, Induced - adverse effects; instrumentation; methods Chorionic Gonadotropin - blood Female Humans Pregnancy

Pregnancy Trimester, First Progesterone - blood Prostaglandins F - adverse effects Prostaglandins F, Synthetic - administration & dosage; therapeutic use Silicone Elastomers

Associated Chemicals: Chorionic Gonadotropin (0) ; Prostaglandins F (0) ; Prostaglandins F, Synthetic (0) ; Silicone Elastomers (0) ; Progesterone (57-83-0)

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