Effect of lysine vasopressin on pentylenetetrazol-induced retrograde amnesia in rats.

Full Abstract

Lysine vasopressin (1 microgram/rat SC) administered 1 hr prior to either the acquisition trial or 24 hr retention trial facilitated passive avoidance retention. Amnesia was produced when a single 50 mg/kg (IP) injection of pentylenetetrazol was given immediately following the passive avoidance acquisition trial. A single injection of lysine vasopressin (1 microgram/rat SC) administered 1 hr prior to either the acquisition trial or 24 hr retention trial antagonized the amnesia.

Author information

Author/s: Bookin, H B (HB); Pfeifer, W D (WD);

Journal and publication information

Publication Type: Journal Article

Journal: Pharmacology, biochemistry, and behavior (Pharmacol Biochem Behav), published in UNITED STATES. (Language: eng)

Reference: 1977-Jul; vol 7 (issue 1) : pp 51-4

Dates: Created 1977/11/25; Completed 1977/11/25; Revised 2006/11/15;

PMID: 561964, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

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