Research article summary (published 30 Dec 1982):

Recent advances in Gilles de la Tourette syndrome: implications for clinical practice and future research.

Full Abstract

The clinical presentation and natural history of Gilles de la Tourette syndrome (TS) are reviewed. The waxing and waning of symptoms, the rostrocaudal progression of areas of motor involvement, complex stereotypies, and the familial aggregation of TS and chronic multiple tics are suggestions of underlying neurochemical disturbance; whereas attentional problems, impulsivity and obsessive-compulsive behaviors create interesting links with other disorders. The most robust metabolic findings are the lowered CSF HVA in many TS patients, and the positive response of symptoms to dopamine blockers and clonidine particularly, which would be consistent with dopamine receptor hypersensitivity and possible noradrenergic-dopaminergic interactions in TS. However, no definitive account of patho-physiology or genetic contributions to the disorder is yet available.

Author information

Author/s: Leckman, J F (JF); Cohen, D J (DJ);

Grants: HD-03008 (Agency:NICHD NIH HHS) ; MH 30929 (Agency:NIMH NIH HHS)

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review

Journal: Psychiatric developments (Psychiatr Dev), published in ENGLAND. (Language: eng)

Reference: 1983-; vol 1 (issue 3) : pp 301-16

Dates: Created 1984/05/11; Completed 1984/05/11; Revised 2007/11/14;

PMID: 6324164, status: MEDLINE (last retrieved date: 2/18/2009)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

External Links for this article
(including full text providers, if available):

Click Electronic Full-text Provider Links to see options for finding the electronic full text links to this article. Note there may be a subscription or fee required for access to the full text. See our FAQ for information on finding FREE full text articles.

This article may also be located in paper journal collections available in many libraries. Use the Journal and Publication Information above to find the full article.

MeSH headings (categories)

This article was linked to the MeSH Headings (categories) shown below.

Adolescent Age Factors Attention Deficit Disorder with Hyperactivity - complications Child Clonidine - therapeutic use Compulsive Behavior - complications Dopamine - metabolism Female Haloperidol - therapeutic use Homovanillic Acid - cerebrospinal fluid Humans

Humans Male Obsessive Behavior - complications Obsessive-Compulsive Disorder - complications Parasympathomimetics - therapeutic use Physostigmine - therapeutic use Receptors, Adrenergic - physiology Serotonin - physiology Sex Factors Tic Disorders - physiopathology Tourette Syndrome - drug therapy; genetics; physiopathology

Note: Bold headings indicate primary MeSH headings or qualifiers.

Associated Chemicals: Parasympathomimetics (0) ; Receptors, Adrenergic (0) ; Homovanillic Acid (306-08-1) ; Clonidine (4205-90-7) ; Serotonin (50-67-9) ; Dopamine (51-61-6) ; Haloperidol (52-86-8) ; Physostigmine (57-47-6)

Related articles

These are the most related articles currently in our database:

• Tourette's syndrome in Monroe County school children. 28 Feb 1988
• Obsessive compulsive symptoms in Gilles de la Tourette syndrome and obsessive compulsive disorder: differences by diagnosis and family history. 23 Jul 1997
• [Tourette syndrome. Genetics, neuroanatomy and neurotransmitters] 23 Aug 2008
• Prolactin in childhood obsessive-compulsive disorder: clinical correlates and response to clomipramine. 27 Feb 1991
• Clinical symptomatology, CSF neurotransmitter metabolites, and serum haloperidol levels in Tourette syndrome. 30 Dec 1981
• HMPAO SPET does not distinguish obsessive-compulsive and tic syndromes in families multiply affected with Gilles de la Tourette's syndrome. 29 Apr 1997
• Rebound phenomena in Tourette's syndrome after abrupt withdrawal of clonidine. Behavioral, cardiovascular, and neurochemical effects. 29 Nov 1986
• Tourette syndrome in oriental children: clinical and pathophysiological considerations. 30 Dec 1981
• Tic disorders. 29 Nov 1997

See 100+ related articles.

Related Article Map

Legend: - FREE Full text Article. - Abstract only. - Title only. More help.

See a larger map of 100+ related articles.