Alteration of the blood-retinal barrier in experimental diabetes mellitus.

Full Abstract

Vitreous fluorophotometry was used to evaluate the integrity of the blood-retinal barrier to fluorescein in hooded rats. Streptozotocin-induced diabetes mellitus caused a breakdown of this barrier within ten days. Normalization of blood glucose levels with insulin significantly reduced (P less than .005) the increased permeability. This functional microangiopathy might prove to be the earliest detectable change in the retinal circulation in experimental diabetes.

Author information

Author/s: Waltman, S (S); Krupin, T (T); Hanish, S (S); Oestrich, C (C); Becker, B (B);

Journal and publication information

Publication Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.

Journal: Archives of ophthalmology (Arch Ophthalmol), published in UNITED STATES. (Language: eng)

Reference: 1978-May; vol 96 (issue 5) : pp 878-9

Dates: Created 1978/07/15; Completed 1978/07/15; Revised 2006/11/15;

PMID: 655925, status: MEDLINE (last retrieved date: 2/18/2009)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

External Links for this article
(including full text providers, if available):

Click Electronic Full-text Provider Links to see options for finding the electronic full text links to this article. Note there may be a subscription or fee required for access to the full text. See our FAQ for information on finding FREE full text articles.

This article may also be located in paper journal collections available in many libraries. Use the Journal and Publication Information above to find the full article.