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| Research article summary (published 30 Aug 1983): |
The sensitization potential of D & C Yellow No. 11 in guinea pigs.
Full Abstract
The certified drug and cosmetic dye substance known as D & C Yellow No. 11 [2-(2-quinolyl)-1,3 indandione] was tested for its dermal sensitization potential in guinea pigs. An induction regimen consisting of a single footpad injection of Complete Freund's Adjuvant diluted with antigen, and an intradermal injection of antigen, produced delayed-type hypersensitivity reactions. A high sensitization frequency was observed with 50 micrograms D & C Yellow No. 11 and the positive control 2,4-dinitrochlorobenzene (DNCB). The reaction severities of both DNCB and 50 micrograms D & C Yellow No. 11 were comparable. A dose-response profile was obtained with D & C Yellow No. 11 employing several concentrations (50, 250 and 500 micrograms/ml). Histologic examination of selected skin sites demonstrated a cellular inflammatory response which was consistent with delayed-type hypersensitivity.
Author information
Author/s: Palazzolo, M J (MJ); DiPasquale, L C (LC);
Journal and publication information
Publication Type: Comparative Study; Journal Article
Journal: Contact dermatitis (Contact Dermatitis), published in DENMARK. (Language: eng)
Reference: 1983-Sep; vol 9 (issue 5) : pp 367-71
Dates: Created 1983/12/20; Completed 1983/12/20; Revised 2006/11/15;
PMID: 6685013, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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