Amnesia attenuation specificity: propranolol reverses norepinephrine but not cycloheximide-induced amnesia.

Full Abstract

Post-trial injections of norepinephrine (NE) or cycloheximide (CHX) into the amygdala produces a long-term retention deficity (amnesia) for a 1-trial footshock experience in rats. concomitant post-trial injections of the adrenergic antagonist, propranolol, prevents NE-, but not CHX-induced amnesia. These results indicate separate mechanisms of action for amnesia produced by intracranial CHX and NE injections.

Author information

Author/s: Ellis, M E (ME); Berman, R F (RF); Kesner, R P (RP);

Grants: 1 R02 MH 3245-01 (Agency:NIMH NIH HHS) ; RR 07092-12 (Agency:NCRR NIH HHS)

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

Journal: Pharmacology, biochemistry, and behavior (Pharmacol Biochem Behav), published in UNITED STATES. (Language: eng)

Reference: 1983-Nov; vol 19 (issue 5) : pp 733-6

Dates: Created 1984/01/27; Completed 1984/01/27; Revised 2007/11/14;

PMID: 6685879, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

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