Reduced umbilical artery prostacyclin formation in complicated pregnancies.

Full Abstract

Prostacyclin synthesis is severely depressed in the umbilical arteries of neonates of mothers with gestational diabetes mellitus, juvenile-onset diabetes mellitus, or preeclamptic symptoms, and of mothers who smoke during pregnancy and diabetic mothers who smoke. The reduced production of prostacyclin might be responsible for an increased abortion rate and a higher rate of intrauterine fetal death because of a decrease in placental perfusion and umbilical blood flow.

Author information

Author/s: Dadak, C (C); Kefalides, A (A); Sinzinger, H (H); Weber, G (G);

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: American journal of obstetrics and gynecology (Am J Obstet Gynecol), published in UNITED STATES. (Language: eng)

Reference: 1982-Dec; vol 144 (issue 7) : pp 792-5

Dates: Created 1983/01/07; Completed 1983/01/07; Revised 2006/11/15;

PMID: 6756150, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

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