Pemoline, methylphenidate, and placebo in children with minimal brain dysfunction.

Full Abstract

An eight-week double-blind comparison between pemoline (Cylert), methylphenidate (Ritalin) hydrochloride, and placebo was carried out on 60 hyperactive children. Measurements of home, school, achievement, cognitive function, and global clinical status were made at baseline, midtreatment, end of treatment, and posttreatment. Both drugs produced improvement in all areas except the achievement measures. One major difference between drugs was the apparently longer action of pemoline, since its effects at home and school tended to persist when the drug was withdrawn, whereas the patients receiving methylphenidate tended to regress to their baseline levels.

Author information

Author/s: Conners, C K (CK); Taylor, E (E);

Journal and publication information

Publication Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, P.H.S.

Journal: Archives of general psychiatry (Arch Gen Psychiatry), published in UNITED STATES. (Language: eng)

Reference: 1980-Aug; vol 37 (issue 8) : pp 922-30

Dates: Created 1980/10/27; Completed 1980/10/27; Revised 2006/11/15;

PMID: 7406656, status: MEDLINE (last retrieved date: 2/18/2009)

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