Research article summary (published 30 Aug 1995):

Risperidone treatment of children and adolescents with chronic tic disorders: a preliminary report.

Full Abstract

OBJECTIVE: The purpose of this trial was to investigate the short-term safety and efficacy of risperidone in the treatment of chronic tic disorders in children and adolescents. METHOD: This was an 11-week open-label trial and included seven subjects (five boys and two girls) with a mean age of 12.9 +/- 1.9 years. The sample included five patients with Tourette's syndrome and two with chronic motor tic disorder. The children were seen at baseline and for two follow-up visits. Three children had a comorbid diagnosis of obsessive-compulsive disorder (OCD). RESULTS: Clinical response, as measured by the Yale Global Tic Severity Scale and the Children's version of the Yale-Brown Obsessive Compulsive Scale, revealed a statistically significant reduction in tic scores ranging from 26% [corrected] to 66%. One of three children with comorbid OCD showed substantial improvement; the other two subjects showed no change. The most frequent side effect was weight gain, which ranged from 8 to 14 lb. CONCLUSIONS: Risperidone, a neuroleptic with both serotonin- and dopamine-blocking properties, appears to be effective in reducing tic frequency and intensity in children and adolescents with chronic tic disorders.

Author information

Author/s: Lombroso, P J (PJ); Scahill, L (L); King, R A (RA); Lynch, K A (KA); Chappell, P B (PB); Peterson, B S (BS); McDougle, C J (CJ); Leckman, J F (JF);

Affiliation: Child Study Center, Yale University School of Medicine, New Haven, CT 06520-7900, USA.

Grants: MH00856 (Agency:NIMH NIH HHS) ; MH30929 (Agency:NIMH NIH HHS) ; MH49351 (Agency:NIMH NIH HHS)

Journal and publication information

Publication Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

Journal: Journal of the American Academy of Child and Adolescent Psychiatry (J Am Acad Child Adolesc Psychiatry), published in UNITED STATES. (Language: eng)

Reference: 1995-Sep; vol 34 (issue 9) : pp 1147-52

Dates: Created 1995/11/09; Completed 1995/11/09; Revised 2007/11/14;

PMID: 7559308, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

Comments and Corrections

CommentIn: J Am Acad Child Adolesc Psychiatry. 1996 Jul;35(7):839-40. (PMID: 8768339)

ErratumIn: J Am Acad Child Adolesc Psychiatry 1996 Mar;35(3):394.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adolescent Antipsychotic Agents - therapeutic use Attention Deficit Disorder with Hyperactivity - complications; drug therapy Child Chronic Disease Dose-Response Relationship, Drug Female Humans

Male Obsessive-Compulsive Disorder - complications; drug therapy Pilot Projects Risperidone - administration & dosage; adverse effects; therapeutic use Severity of Illness Index Tic Disorders - complications; drug therapy Tourette Syndrome - complications; drug therapy Weight Gain

Associated Chemicals: Antipsychotic Agents (0) ; Risperidone (106266-06-2)

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