Research article summary (published 17 Feb 1993):

Selective resistance of tachykinin-responsive cholinergic neurons in the quinolinic acid lesioned neostriatum.

Full Abstract

We have studied changes on endogenous acetylcholine (ACh) release evoked by different agents from rat neostriatal slices after quinolinic acid (QA) injections. QA lesions induced a biphasic decrease on ACh release evoked by 1 microM glutamate and 50 mM KCl. ACh release evoked by selective tachykinin agonists was only significantly decreased by 250 nmol QA. These results suggest the presence of different functional cholinergic cell populations, with tachykinin-responsive cholinergic neurons selectively spared.

Author information

Author/s: Arenas, E (E); Pérez-Navarro, E (E); Alberch, J (J); Marsal, J (J);

Affiliation: Departament de Biologia Cellular i Anatomia Patològica, Hospital de Bellvitge, Universitat de Barcelona, Facultat de Medicina, Spain.

Journal and publication information

Publication Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't

Journal: Brain research (Brain Res), published in NETHERLANDS. (Language: eng)

Reference: 1993-Feb; vol 603 (issue 2) : pp 317-20

Dates: Created 1993/05/03; Completed 1993/05/03; Revised 2006/11/15;

PMID: 7681719, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Acetylcholine - metabolism Animals Dose-Response Relationship, Drug Glutamates - pharmacology Glutamic Acid Male Microinjections Neostriatum - drug effects; pathology; physiology

Neurokinin A - analogs & derivatives; pharmacology Neurons - drug effects; pathology; physiology Peptide Fragments - pharmacology Potassium Chloride - pharmacology Quinolinic Acid - administration & dosage; toxicity Rats Rats, Sprague-Dawley Substance P - analogs & derivatives; pharmacology

Associated Chemicals: Glutamates (0) ; Peptide Fragments (0) ; neurokinin A (4-10), Nle(10)- (110863-33-7) ; substance P, Sar(9)-Met(O2)(11)- (110880-55-2) ; Substance P (33507-63-0) ; Acetylcholine (51-84-3) ; Glutamic Acid (56-86-0) ; Potassium Chloride (7447-40-7) ; Neurokinin A (86933-74-6) ; Quinolinic Acid (89-00-9)

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