Research article summary (published 30 Dec 1994):

Effect of plasma volume expansion on auricular natriuretic peptide in non-dependent insulin diabetic patients with autonomic neuropathy.

Full Abstract

The objective of this study was to determine the role of atrial natriuretic peptide (ANP) in autonomic neuropathy and to learn the effect of saline solution infusion on ANP. Twenty one subjects were distributed in three groups: 1) control group, 2) diabetic patients with autonomic neuropathy, and 3) diabetic patients without autonomic neuropathy. The levels of ANP, renin, aldosterone and cortisol were determined at baseline and 30, 60, and 75 min after saline infusion. At baseline ANP was lower in diabetic patients with autonomic neuropathy (32.9 +/- 13) than control group (34 +/- 15). ANP increased statistically significantly at 30 min after solution administration in control group (60 +/- 35, F = 4, p < 0.05), but it did not change in diabetic patients (Group II: 34.3 +/- 9.3 and Group III 34.6 +/- 10.7). Sixty and 75 min after saline infusion ANP returned to basal levels in control group, but they did not change in diabetic patients. A delayed response of renin, aldosterone and cortisol to saline solution administration was observed in diabetic patients. There was no correlation between ANP levels and alteration of autonomic tests. It is concluded that independent of autonomic neuropathy, the levels of ANP did not increase with saline infusion in diabetic patients.

Author information

Author/s: Salas-Ramírez, M (M); Ariza Andraca, R (R); Frati Munari, A (A); Muñoz, H (H); Altamirano, P (P);

Affiliation: Subjefatura de Investigación Clínica, Instituto Mexicano del Seguro Social, México, D.F.

Journal and publication information

Publication Type: Journal Article

Journal: Archives of medical research (Arch Med Res), published in MEXICO. (Language: eng)

Reference: 1995-; vol 26 (issue 1) : pp 35-40

Dates: Created 1995/05/16; Completed 1995/05/16; Revised 2004/11/17;

PMID: 7711445, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adult Aldosterone - secretion Atrial Natriuretic Factor - blood Autonomic Nervous System Diseases - blood; physiopathology Diabetes Mellitus, Type 2 - blood; physiopathology Diabetic Neuropathies - blood; physiopathology

Humans Hydrocortisone - secretion Middle Aged Plasma Volume Renin - secretion Sodium Chloride - administration & dosage

Associated Chemicals: Hydrocortisone (50-23-7) ; Aldosterone (52-39-1) ; Sodium Chloride (7647-14-5) ; Atrial Natriuretic Factor (85637-73-6) ; Renin (EC 3.4.23.15)

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