Research article summary (published 30 Aug 1994):

Norepinephrine and serotonin alterations following chronic stressor exposure: mouse strain differences.

Full Abstract

Exposure to acute uncontrollable foot shock influenced the levels and utilization of norepinephrine (NE) and serotonin (5-HT) in several brain regions. These effects varied between the BALB/cByJ and C57BL/6J mouse strains, with the former displaying more pronounced amine variations. Following repeated exposure to foot shock over 15 days, the decline of NE associated with an acute stressor was abrogated. In the hypothalamus, this was accompanied by high MHPG accumulation, suggesting that the increased NE stemmed from a compensatory increase in synthesis. In the locus coeruleus and prefrontal cortex the accumulation of MHPG declined with repeated exposure, possibly suggesting moderation in utilization. In animals exposed to a chronic unpredictable stressor regimen, the NE decline in the hypothalamus was precluded, but pronounced NE reductions were still evident in the locus coeruleus and prefrontal cortex. The data are related to behavioral impairments associated with stressor application, as well as to the particular vulnerability of BALB/cByJ mice to stressor-induced behavioral impairments.

Author information

Author/s: Shanks, N (N); Griffiths, J (J); Anisman, H (H);

Affiliation: Douglas Hospital Research Centre, Montreal, Quebec, Canada.

Journal and publication information

Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

Journal: Pharmacology, biochemistry, and behavior (Pharmacol Biochem Behav), published in UNITED STATES. (Language: eng)

Reference: 1994-Sep; vol 49 (issue 1) : pp 57-65

Dates: Created 1995/02/07; Completed 1995/02/07; Revised 2006/11/15;

PMID: 7816890, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Animals Brain Chemistry - physiology Chronic Disease Electroshock Male Mice

Mice, Inbred BALB C Mice, Inbred C57BL Norepinephrine - metabolism Serotonin - metabolism Species Specificity Stress, Psychological - metabolism

Associated Chemicals: Serotonin (50-67-9) ; Norepinephrine (51-41-2)

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