Research article summary (published 29 Nov 1994):

Previous stress increases in vivo biogenic amine response to swim stress.

Full Abstract

In vivo microdialysis was used to determine biogenic amines in medial prefrontal cortex of rats exposed to eight minutes of swim stress on two consecutive days. On the first day of stress, norepinephrine (NE) efflux increased by 183% over baseline after stress, while dopamine (DA) and serotonin (5-HT) remained stable throughout. On the second day of stress, a robust increase was observed in all 3 neurotransmitters measured, with (NE), (DA), and (5-HT) increasing by 310%, 441% and 496% respectively, and remaining elevated for an hour or more after stress. This suggests that the first exposure to swim stress, while not causing dramatic changes in biogenic amine release, may sensitize biogenic amines in medial prefrontal cortex to subsequent swim stress. Our results also serve as preliminary data concerning the neurochemical changes which might underlie the forced swimming model of "behavioral despair".

Author information

Author/s: Jordan, S (S); Kramer, G L (GL); Zukas, P K (PK); Petty, F (F);

Affiliation: Veterans Affairs Medical Center, University of Texas Southwestern Medical School, Dallas.

Grants: AA07234 (Agency:NIAAA NIH HHS) ; MH37899 (Agency:NIMH NIH HHS) ; MH41115 (Agency:NIMH NIH HHS)

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.

Journal: Neurochemical research (Neurochem Res), published in UNITED STATES. (Language: eng)

Reference: 1994-Dec; vol 19 (issue 12) : pp 1521-5

Dates: Created 1995/04/06; Completed 1995/04/06; Revised 2008/11/21;

PMID: 7877723, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Animals Biogenic Monoamines - metabolism Dopamine - metabolism Kinetics Male Norepinephrine - metabolism

Prefrontal Cortex - metabolism Rats Rats, Sprague-Dawley Serotonin - metabolism Stress, Physiological - metabolism Swimming

Associated Chemicals: Biogenic Monoamines (0) ; Serotonin (50-67-9) ; Norepinephrine (51-41-2) ; Dopamine (51-61-6)

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