Research article summary (published 29 Nov 1994):

Differential changes in rat brain noradrenaline turnover produced by continuous and intermittent restraint stress.

Full Abstract

This experiment was performed to investigate differential effects of continuous and intermittent restraint stress on noradrenaline (NA) turnover in brain regions of male Wistar rats by measuring levels of a major metabolite of NA, 3-methoxy-4-hydroxyphenylethyleneglycol sulfate (MHPG-SO4) levels, as well as by measuring levels of plasma corticosterone and organ weights of the thymus, spleen, and adrenal glands. Rats in the 15-min and 30-min intermittently stressed groups showed significantly larger increases in MHPG-SO4 levels in most brain regions relative to those in the 90-min and 180-min continuously stressed groups, even though the total stress duration was equal or shorter. Body weight loss and loss of relative thymus weight in the 15-min intermittently stressed groups were the most marked among the five treatment groups. These findings suggest that stress-rest cyclicity is critical in determining the extent of stress-induced brain NA turnover and peripheral physiological responses.

Author information

Author/s: Shimizu, T (T); Tanaka, M (M); Yokoo, H (H); Gondoh, Y (Y); Mizoguchi, K (K); Matsuguchi, N (N); Tsuda, A (A);

Affiliation: Department of Pharmacology, Kurume University School of Medicine, Japan.

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: Pharmacology, biochemistry, and behavior (Pharmacol Biochem Behav), published in UNITED STATES. (Language: eng)

Reference: 1994-Dec; vol 49 (issue 4) : pp 905-9

Dates: Created 1995/04/12; Completed 1995/04/12; Revised 2006/11/15;

PMID: 7886106, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

External Links for this article
(including full text providers, if available):

Click Electronic Full-text Provider Links to see options for finding the electronic full text links to this article. Note there may be a subscription or fee required for access to the full text. See our FAQ for information on finding FREE full text articles.

This article may also be located in paper journal collections available in many libraries. Use the Journal and Publication Information above to find the full article.

MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Animals Body Weight - physiology Brain Chemistry - physiology Corticosterone - blood Male Methoxyhydroxyphenylglycol - metabolism

Norepinephrine - metabolism Organ Size - physiology Rats Rats, Wistar Restraint, Physical Stress, Psychological - metabolism

Associated Chemicals: Corticosterone (50-22-6) ; Norepinephrine (51-41-2) ; Methoxyhydroxyphenylglycol (534-82-7)

Related articles

These are the highest related articles currently in the database:

• Cerebral protein synthesis alterations in response to acute and chronic immobilization stress in the rat. 25 Mar 1995
• Behavioral and neurochemical changes in response to acute stressors: influence of previous chronic exposure to immobilization. 29 Jun 1992
• Periodic maternal deprivation alters stress response in adult offspring: potentiates the negative feedback regulation of restraint stress-induced adrenocortical response and reduces the frequencies of open field-induced behaviors. 29 Nov 1994
• Stressor-induced alterations of natural killer cell activity and central catecholamines in mice. 30 May 1991
• Effect of isolation stress on brain mast cells and brain histamine levels in rats. 30 May 1994
• Brain regional serotonin synthesis following adaptation to repeated restraint. 6 Sep 1994
• Effects of hyperactivity of the maternal hypothalamic-pituitary-adrenal (HPA) axis during pregnancy on the development of the HPA axis and brain monoamines of the offspring. 30 Oct 1994
• Contribution of noradrenergic neurons to 3,4-dihydroxyphenylacetic acid concentrations in the regions of the rat brain containing incertohypothalamic dopaminergic neurons. 24 Jul 1991
• Estimation of the biophase concentration of noradrenaline at presynaptic alpha 2-adrenoceptors in brain slices. 30 Mar 1992

See 100+ related articles.

Related Article Map

Legend: - FREE Full text Article. - Abstract only. - Title only. More help.

See a large map of 100+ related articles.