Research article summary (published 30 Oct 1994):

Effects of selective dopamine receptor compounds on single, spontaneously-active neostriatal neurons.

Full Abstract

1. The effects of selective dopamine receptor compounds on the spontaneous activity of single neostriatal neurons were examined extracellularly. 2. Intravenous administration of quinpirole, the D2 agonist, elicited a dose-dependent depression in discharge rate. 3. Quinpirole-evoked depression was reversed by the D2 antagonist eticlopride, but not the D1 antagonist SCH 23390. 4. The partial D1 agonist, SKF 38393 induced depression and excitation in equal proportion. 5. A dose of 0.25 mg/kg SCH 23390 blocked SKF 38393-induced depression but not excitation. 6. SKF 38393-induced excitation was antagonized by eticlopride and in some cases by a higher dose of SCH 23390.

Author information

Author/s: Nantwi, K D (KD); Schoener, E P (EP);

Affiliation: Department of Pharmacology, School of Medicine, Wayne State University, Detroit, MI 48201.

Journal and publication information

Publication Type: Journal Article

Journal: General pharmacology (Gen Pharmacol), published in ENGLAND. (Language: eng)

Reference: 1994-Nov; vol 25 (issue 7) : pp 1439-43

Dates: Created 1995/04/24; Completed 1995/04/24; Revised 2008/11/21;

PMID: 7896058, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine - antagonists & inhibitors; pharmacology Animals Benzazepines - pharmacology Depression, Chemical Dopamine Agonists - pharmacology Dopamine Antagonists - pharmacology Ergolines - antagonists & inhibitors; pharmacology Male

Neostriatum - drug effects; physiology; ultrastructure Neurons - drug effects; physiology; ultrastructure Quinpirole Rats Rats, Sprague-Dawley Receptors, Dopamine D1 - drug effects Receptors, Dopamine D2 - drug effects Salicylamides - pharmacology

Associated Chemicals: Benzazepines (0) ; Dopamine Agonists (0) ; Dopamine Antagonists (0) ; Ergolines (0) ; Receptors, Dopamine D1 (0) ; Receptors, Dopamine D2 (0) ; Salicylamides (0) ; 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine (67287-49-4) ; eticlopride (84226-12-0) ; Quinpirole (85760-74-3)

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