Discriminative stimulus properties of 7-OH-DPAT, a dopamine D3-selective receptor ligand.

Full Abstract

7-Hydroxy-N,N-di-n-propyl-2-aminotetralin (7-OH-DPAT) is a high affinity and selective ligand at dopamine D3 receptors. Rats were trained to discriminate 7-OH-DPAT (0.05 mg/kg) from drug vehicle using a food-reinforced (FR 10) two-lever operant procedure. Six out of nine rats learned to discriminate 7-OH-DPAT, requiring a mean of 29 training sessions. After the training dose was increased to 0.10 mg/kg the remaining three rats reached discrimination performance criterion. The 7-OH-DPAT stimulus was dose-dependent. Doses of 0.01, 0.03, 0.056, and 0.1 mg/kg 7-OH-DPAT produced 0, 11, 78, and 100% drug-correct lever selection, respectively, with the ED50 value calculated to be 0.038 mg/kg. These results demonstrate that the D3-selective ligand 7-OH-DPAT can control differential operant responding in rats on the basis of its discriminative stimulus properties.

Author information

Author/s: McElroy, J F (JF);

Affiliation: DuPont Merck Pharmaceutical Company, Wilmington, DE 19880-0400.

Journal and publication information

Publication Type: Journal Article

Journal: Pharmacology, biochemistry, and behavior (Pharmacol Biochem Behav), published in UNITED STATES. (Language: eng)

Reference: 1994-Jun; vol 48 (issue 2) : pp 531-3

Dates: Created 1994/10/20; Completed 1994/10/20; Revised 2005/11/17;

PMID: 7916465, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Male
Rats
Rats, Sprague-Dawley
Receptors, Dopamine - drug effects
Receptors, Dopamine D2
Receptors, Dopamine D3
Tetrahydronaphthalenes - pharmacology

Associated Chemicals: Dopamine Agents (0) ; Drd3 protein, rat (0) ; Receptors, Dopamine (0) ; Receptors, Dopamine D2 (0) ; Receptors, Dopamine D3 (0) ; Tetrahydronaphthalenes (0) ; 7-hydroxy-2-N,N-dipropylaminotetralin (74938-11-7)

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