Research article summary (published 30 Jul 1994):

[Effects of metals (silver, nickel, cobalt and chromium) on the reactive oxygen species generating capacity of human neutrophils and on the serum opsonic activity]

Full Abstract

Many metal materials are used in clinical medicine and the number used is increasing. However, there are a few papers concerning the biological effects, especially effects of clinically used metals on cellular immunity. In this paper, silver (Ag), nickel (Ni), cobalt (Co), and chromium (Cr), clinically commonly used metals, the effects of which on neutrophilic activity have already reported using the luminol-dependent chemiluminescence (LDCL) method, were examined to determine their influence on the reactive oxygen species (ROS) generating capacity of human neutrophils and on a serum opsonic activity. Silver suppressed the ROS generating capacity of neutrophils in a dose-dependent manner but did not affect the serum opsonic activity. Nickel also suppressed the ROS generating capacity of neutrophils but, at some concentrations, caused the serum opsonic activity to increase. In contrast, Cobalt increased both the ROS generating capacity of neutrophils and the serum opsonic activity. Like silver, chromium did not affect the serum opsonic activity and suppressed the ROS generating capacity of neutrophils. However, the suppression of ROS generating by chromium occurred differently from that of silver. In the cases of nickel and cobalt, effects of these metals on hemolyzing activity of serum complements (CH-50) were measured and consumption of complements was observed at the same metal concentration at which serum opsonic activity was elevated. In this paper, we report that some metals influence not only the ROS generating capacity of neutrophils but also the serum opsonic activity, results thought to be important for more details studies of the effects of metals on cellular immunity.

Author information

Author/s: Ono, Y (Y); Nakaji, S (S); Sugawara, K (K); Kumae, T (T);

Affiliation: Department of Hygiene, Hirosaki University School of Medicine, Japan.

Journal and publication information

Publication Type: English Abstract; Journal Article

Journal: Nippon eiseigaku zasshi. Japanese journal of hygiene (Nippon Eiseigaku Zasshi), published in JAPAN. (Language: jpn)

Reference: 1994-Aug; vol 49 (issue 3) : pp 645-53

Dates: Created 1994/11/16; Completed 1994/11/16; Revised 2006/11/15;

PMID: 7933650, status: MEDLINE (last retrieved date: 2/18/2009)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MeSH Headings (categories) shown below.

Cells, Cultured Chromium - pharmacology Cobalt - pharmacology Humans Immunity, Cellular - drug effects Male

Metals - pharmacology Neutrophils - immunology; metabolism Nickel - pharmacology Opsonin Proteins - blood Reactive Oxygen Species - metabolism Silver - pharmacology

Note: Bold headings indicate primary MeSH headings or qualifiers.

Associated Chemicals: Metals (0) ; Opsonin Proteins (0) ; Reactive Oxygen Species (0) ; Nickel (7440-02-0) ; Silver (7440-22-4) ; Chromium (7440-47-3) ; Cobalt (7440-48-4)

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