Electrical stimulation of the dorsal raphe nucleus as a discriminative stimulus: generalization to (+/-)-DOI.

Full Abstract

Electrical stimulation of the dorsal raphe nucleus of Sprague-Dawley rats was used as the cue for discrimination using a taste aversion paradigm. Rats were trained to associate saccharin drinking during electrical stimulation of the dorsal raphe nucleus with LiCl injection after the session as the aversive unconditioned stimulus. In sessions without stimulation, rats were allowed to consume saccharin and received a saline injection after the session. Suppression of saccharin consumption during electrical stimulation was learned within 12 trials. Rats trained in the reverse discrimination, i.e., sessions with no electrical stimulation paired with LiCl injection, showed a similar learning curve. Animals injected prior to the session with the hallucinogenic 5-HT2 agonist (+/-)-DOI associated DOI with electrical stimulation of the dorsal raphe nucleus. Thus, animals may be trained to discriminate electrical stimulation of the dorsal raphe nucleus. Furthermore, animals generalize from activation of 5-HT2 receptors to electrical stimulation of the dorsal raphe nucleus.

Author information

Author/s: Mokler, D J (DJ); Dixon, M (M); Stambaugh, L (L);

Affiliation: Department of Pharmacology, University of New England, College of Osteopathic Medicine, Biddeford, ME 04005.

Journal and publication information

Publication Type: Journal Article

Journal: Pharmacology, biochemistry, and behavior (Pharmacol Biochem Behav), published in UNITED STATES. (Language: eng)

Reference: 1994-Aug; vol 48 (issue 4) : pp 1041-5

Dates: Created 1994/12/29; Completed 1994/12/29; Revised 2003/11/14;

PMID: 7972283, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Amphetamines - pharmacology
Animals
Cues
Discrimination Learning - drug effects
Electric Stimulation
Generalization, Stimulus - drug effects
Lithium Chloride - pharmacology

Associated Chemicals: Amphetamines (0) ; Serotonin Agonists (0) ; 4-iodo-2,5-dimethoxyphenylisopropylamine (64584-34-5) ; Lithium Chloride (7447-41-8)

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