Research article summary (published 4 Jan 1994):

Components of wingless signalling in Drosophila.

Full Abstract

The determination of specific cell fates and polarity within each segmental unit of the Drosophila embryo involves the products of the segment polarity genes. One of these, wingless (wg), encodes a secreted protein that is homologous to the mammalian proto-oncogene Wnt-1 (refs 4, 5). In the embryonic epidermis, wg is expressed in a single row of cells within each segmental unit, although its activity is required for the correct patterning of most of the epidermis. Initially Wg signals to adjacent posterior cells, maintaining engrailed (en) expression. Later during embryogenesis, wg specifies the differentiation of naked cuticle. Wg signalling functions by inactivating or antagonizing the activity of zestewhite 3 (zw3). We have investigated the requirement in the Wg signal transduction pathway for the three genes armadillo (arm), dishevelled (dsh) and porcupine (porc), all of which have embryonic mutant phenotypes similar to wg. Our results indicate that dsh and porc act upstream of zw3, and arm acts downstream of zw3.

Author information

Author/s: Siegfried, E (E); Wilder, E L (EL); Perrimon, N (N);

Affiliation: Department of Genetics, Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02115.

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

Journal: Nature (Nature), published in ENGLAND. (Language: eng)

Reference: 1994-Jan; vol 367 (issue 6458) : pp 76-80

Dates: Created 1994/03/21; Completed 1994/03/21; Revised 2008/11/21;

PMID: 8107779, status: MEDLINE (last retrieved date: 2/18/2009)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MeSH Headings (categories) shown below.

Adaptor Proteins, Signal Transducing Animals Armadillo Domain Proteins Cell Polarity Crosses, Genetic Drosophila - embryology; genetics; metabolism Drosophila Proteins Female Gene Expression Regulation Genotype Insect Hormones - genetics; metabolism

Insect Hormones - genetics; metabolism Larva Male Mutation Phosphoproteins Proteins - genetics; metabolism Proto-Oncogene Proteins - genetics; metabolism Signal Transduction Trans-Activators Transcription Factors Wnt1 Protein

Note: Bold headings indicate primary MeSH headings or qualifiers.

Associated Chemicals: Adaptor Proteins, Signal Transducing (0) ; Armadillo Domain Proteins (0) ; Drosophila Proteins (0) ; Insect Hormones (0) ; Phosphoproteins (0) ; Proteins (0) ; Proto-Oncogene Proteins (0) ; Trans-Activators (0) ; Transcription Factors (0) ; Wnt1 Protein (0) ; armadillo protein, Drosophila (0) ; dishevelled proteins (0) ; wg protein, Drosophila (0)

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