Correlation of altered Q-T interval and sympathetic nervous system dysfunction in diabetic autonomic neuropathy.

Full Abstract

We examined the relationship between the Q-T interval and autonomic dysfunction in 74 diabetic patients and age-matched controls. The expected Q-T interval was standardized as a function of the R-R interval in 646 healthy controls, and the delta Q-T defined as the difference from the expected value. Propranolol increased delta Q-T, confirming this as a parameter of autonomic function. No relationship between delta Q-T and duration of disease, glucose control, retinopathy or proteinuria was observed. However, significant correlations were found between the delta Q-T and delay of nerve conduction velocity, orthostatic hypotension, altered Valsalva ratio, abnormal Valsalva overshoot, cold pressor response, decreased norepinephrine concentration and sympathetic function score in diabetic patients.

Author information

Author/s: Oka, H (H); Mochio, S (S); Sato, K (K); Isogai, Y (Y);

Affiliation: Third Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan.

Journal and publication information

Publication Type: Journal Article

Journal: European neurology (Eur Neurol), published in SWITZERLAND. (Language: eng)

Reference: 1994-; vol 34 (issue 1) : pp 23-9

Dates: Created 1994/04/25; Completed 1994/04/25; Revised 2004/11/17;

PMID: 8137835, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

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