Pentylenetetrazol-induced amnesia: a case for overt seizures.

Full Abstract

In this study, the possible role of overt convulsions following pentylenetetrazol (PTZ) in retrograde amnesia was investigated. Following a single passive avoidance conditioning, when overt convulsions were blocked with sodium pentobarbital (Nem), the amnesic effect of pentylenetetrazol was also blocked. Subconvulsive doses of the drug did not produce amnesia. Animals that received a typically convulsive dose of the drug but failed to convulse were not amnesic; only animals with overt convulsions were different from saline controls. The data suggest that overt convulsions may be necessary for the development of pentylenetetrazol-induced retrograde amnesia.

Author information

Author/s: Palfai, T (T); Albala, B (B);

Journal and publication information

Publication Type: Journal Article

Journal: Psychopharmacology (Psychopharmacology (Berl)), published in GERMANY, WEST. (Language: eng)

Reference: 1976-Jul; vol 48 (issue 1) : pp 19-23

Dates: Created 1976/12/01; Completed 1976/12/01; Revised 2004/11/17;

PMID: 823568, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

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