Research article summary (published 30 Aug 1993):

Group sequential tests for bivariate response: interim analyses of clinical trials with both efficacy and safety endpoints.

Full Abstract

We describe group sequential tests for a bivariate response. The tests are defined in terms of the two response components jointly, rather than through a single summary statistic. Such methods are appropriate when the two responses concern different aspects of a treatment; for example, one might wish to show that a new treatment is both as effective and as safe as the current standard. We present a formulation of the bivariate testing problem, introduce group sequential tests that satisfy Type I error conditions, and show how to find the sample size guaranteeing a specified power. We describe how properties of group sequential tests for bivariate normal observations can be computed by numerical integration.

Author information

Author/s: Jennison, C (C); Turnbull, B W (BW);

Affiliation: School of Mathematical Sciences, University of Bath, United Kingdom.

Grants: R01 GM28364 (Agency:NIGMS NIH HHS)

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

Journal: Biometrics (Biometrics), published in UNITED STATES. (Language: eng)

Reference: 1993-Sep; vol 49 (issue 3) : pp 741-52

Dates: Created 1993/12/29; Completed 1993/12/29; Revised 2007/11/15;

PMID: 8241370, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

External Links for this article
(including full text providers, if available):

Click Electronic Full-text Provider Links to see options for finding the electronic full text links to this article. Note there may be a subscription or fee required for access to the full text. See our FAQ for information on finding FREE full text articles.

This article may also be located in paper journal collections available in many libraries. Use the Journal and Publication Information above to find the full article.

MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Biometry - methods Clinical Trials as Topic - statistics & numerical data Data Interpretation, Statistical Evaluation Studies as Topic

Evaluation Studies as Topic Humans Models, Statistical Safety

Related articles

These are the highest related articles currently in the database:

• Estimating the ventilation-perfusion distribution: an ill-posed integral equation problem. 28 Feb 1992
• The new biostatistics of resampling. 27 Feb 1995
• Resampling: a good tool, no panacea. 27 Feb 1995
• Relative incidence estimation from case series for vaccine safety evaluation. 27 Feb 1995
• Weighted least squares analysis of repeated categorical measurements with outcomes subject to nonresponse. 27 Feb 1994
• Intraclass correlation for two-by-two tables under three sampling designs. 27 Feb 1994
• Models for three-dimensional contingency tables with completely and partially cross-classified data. 27 Feb 1994
• Estimation of the infection time and latency distribution of AIDS with doubly censored data. 27 Feb 1994
• Slope estimation in the presence of informative right censoring: modeling the number of observations as a geometric random variable. 27 Feb 1994

See 100+ related articles.

Related Article Map

Legend: - FREE Full text Article. - Abstract only. - Title only. More help.

See a large map of 100+ related articles.