Research article summary (published 30 Dec 1992):

Somatostatin receptor scintigraphy in brain tumors and pituitary tumors: first experiences.

Full Abstract

Somatostatin receptors have been demonstrated on various tumors of neuroendocrine and other origin. They have been detected in vitro by biochemical techniques as well as by autoradiography. The development of long-acting somatostatin analogs and the recent availability of radiolabeled octreotide have made the in vivo detection of somatostatin receptors possible. This preliminary study embraced 45 patients with meningiomas, brain tumors or pituitary tumors, which were imaged by planar and tomographic scintigraphy after intravenous injection of 111Indium-labeled octreotide. In all of the meningiomas studied (unifocal and multifocal tumors in various locations), a high density of somatostatin receptors was detected by scintigraphy. Pituitary tumors were slightly positive in 50% of cases only, independent of the endocrine activity. Gliomas with an intact blood-brain barrier showed no enhanced tracer uptake in vivo, while gliomas with disturbed blood-brain barrier had a high activity uptake. We conclude that in vivo somatostatin receptor scintigraphy, although not tumor-specific, may aid in the preoperative diagnosis and staging of intracranial tumors, especially skull base tumors.

Author information

Author/s: Scheidhauer, K (K); Hildebrandt, G (G); Luyken, C (C); Schomäcker, K (K); Klug, N (N); Schicha, H (H);

Affiliation: Department of Nuclear Medicine, University of Cologne, Germany.

Journal and publication information

Publication Type: Journal Article

Journal: Hormone and metabolic research. Supplement series (Horm Metab Res Suppl), published in GERMANY. (Language: eng)

Reference: 1993-; vol 27 (issue ) : pp 59-62

Dates: Created 1993/08/13; Completed 1993/08/13; Revised 2007/07/23;

PMID: 8330874, status: MEDLINE (last retrieved date: 2/18/2009)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MeSH Headings (categories) shown below.

Adult Aged Brain Neoplasms - pathology; radionuclide imaging Female Growth Hormone - analysis Humans Indium Radioisotopes - diagnostic use Male

Meningeal Neoplasms - radionuclide imaging Meningioma - radionuclide imaging Middle Aged Octreotide - analogs & derivatives; diagnostic use Pentetic Acid - analogs & derivatives; diagnostic use Pituitary Neoplasms - pathology; radionuclide imaging Receptors, Somatostatin - analysis Tumor Markers, Biological - analysis

Note: Bold headings indicate primary MeSH headings or qualifiers.

Associated Chemicals: Indium Radioisotopes (0) ; Receptors, Somatostatin (0) ; Tumor Markers, Biological (0) ; SDZ 215-811 (142694-57-3) ; Pentetic Acid (67-43-6) ; Octreotide (83150-76-9) ; Growth Hormone (9002-72-6)

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