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| Research article summary (published 30 Mar 1993): |
Induction of prothrombin biosynthesis and inhibition of gamma carboxylase activity in experimental models of liver regeneration and fibrosis.
Full Abstract
1. When acute liver damage is induced in rats treated with CCl4, both prothrombin biosynthesis and gamma carboxylase activity decreases, originating a prolongation of prothrombin time in plasma. 2. Then, during the regenerative process, prothrombin biosynthesis increases higher than normal, but gamma carboxylase activity remain decreased. In this case, prolongation of prothrombin time occurs in spite of high levels of descarboxylated prothrombin in plasma. 3. An increase of descarboxylated prothrombin in plasma is also detected in the CCl4-liver fibrosis model.
Author information
Author/s: Panduro, A (A); Valencia, J (J); Rojkind, M (M);
Affiliation: Department of Gastroenterology, Instituto Nacional de la Nutrición S.Z., Tlalpan, México, D.F.
Journal and publication information
Publication Type: Journal Article
Journal: The International journal of biochemistry (Int J Biochem), published in ENGLAND. (Language: eng)
Reference: 1993-Apr; vol 25 (issue 4) : pp 525-32
Dates: Created 1993/05/11; Completed 1993/05/11; Revised 2006/11/15;
PMID: 8467953, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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