Research article summary (published 30 Aug 1995):

Autoradiographical study of types 1 and 2 of benzodiazepine receptors in rat brain after chronic ethanol treatment and its withdrawal.

Full Abstract

The effect of chronic ethanol treatment, and its withdrawal on benzodiazepine binding sites in rat brain is described in this autoradiographical study using the benzodiazepine agonist [3H]flunitrazepam. Several areas of the rat cerebral cortex, hippocampus, mesencephalon, cerebellum and lateral geniculate nucleus were studied in animals, chronically treated with ethanol, and 24 or 48 hr after ethanol withdrawal. The [3H]flunitrazepam binding and the relative percentages of binding to BZ1 and BZ2 sites, using zolpidem as a BZ1 site inhibitor, are described. The cerebellum and red nucleus, which only express BZ1 binding sites, appear to be areas significantly modified by ethanol and its withdrawal. In no other structure did ethanol modify [3H]flunitrazepam binding nor change the relative percentage of BZ1 and BZ2 sites.

Author information

Author/s: Negro, M (M); Fernández-López, A (A); Calvo, P (P);

Affiliation: Department of Biochemistry and MOlecular Biology, University of León, Spain.

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: Neuropharmacology (Neuropharmacology), published in ENGLAND. (Language: eng)

Reference: 1995-Sep; vol 34 (issue 9) : pp 1177-82

Dates: Created 1996/01/26; Completed 1996/01/26; Revised 2006/11/15;

PMID: 8532188, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Animals Autoradiography Brain - drug effects Ethanol - pharmacology Flunitrazepam - pharmacology Male

Radioligand Assay Rats Rats, Wistar Receptors, GABA-A - drug effects Substance Withdrawal Syndrome gamma-Aminobutyric Acid - pharmacology

Associated Chemicals: Receptors, GABA-A (0) ; Flunitrazepam (1622-62-4) ; gamma-Aminobutyric Acid (56-12-2) ; Ethanol (64-17-5)

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