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| Research article summary (published 30 Dec 1994): |
Experimental toxic liver damage and hepatic plasma clearance of 99mTc-mebrofenin (iminodiacetate derivative). III. Chronic CCl4-induced liver damage with eventual cirrhosis in rabbits.
Full Abstract
Chronic damage to liver parenchyma was induced in rabbits by the long-term administration of carbon tetrachloride. The animals were serially sacrificed 3, 6 and 9 months after the start of intoxication, and examined histopathologically. The biological response was qualitatively assessed from results of histological studies, and measured utilizing series of typical biochemical indices of liver damage, 99mTc-mebrofenin (an-IDA-derivative) plasma clearance by the liver, and quantified indices of uptake and organ transfer of the compound. It was found that the plasma clearance and transfer parameters show association with chronic liver damage. The reduction of plasma 99mTc-mebrofenin clearance in intoxicated rabbits was also associated with changes in the biochemical indices of liver function and damage.
Author information
Author/s: Kapuscinski, J (J); Kuroszczyk, J (J); Liniecki, J (J); Bienkiewicz, M (M); Tuszyner, K (K);
Affiliation: Department of Nuclear Medicine, Medical University Lodz, Poland.
Journal and publication information
Publication Type: Journal Article
Journal: International journal of occupational medicine and environmental health (Int J Occup Med Environ Health), published in POLAND. (Language: eng)
Reference: 1995-; vol 8 (issue 3) : pp 255-65
Dates: Created 1996/03/20; Completed 1996/03/20; Revised 2003/11/14;
PMID: 8581333, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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