Biologically active principles isolated from Salacia oblonga wall.

Full Abstract

From the petroleum ether extract of the root bark of Salacia Oblonga wall, two biologically active fractions have been isolated by column and thin layer chromatography. The methanol eluted fraction of the extract absorbed on a column of silica gel at a concentration of 50 micrograms/ml showed 100 percent cytotoxicity on Ehrlich ascites tumour cells. The chloroform eluted fraction of the pet. ether extract and a fluorescent compound separated from it by TLC demonstrated about 60% and 76% hypoglycemic potency of an equal dose of tolbutamide (250 mg/kg) in albino rats. The results indicate the therapeutic importance of S. Oblonga wall.

Author information

Author/s: Augusti, K T (KT); Joseph, P (P); Babu, T D (TD);

Affiliation: Amala Cancer Research Centre, Thrissur.

Journal and publication information

Publication Type: Comparative Study; Journal Article

Journal: Indian journal of physiology and pharmacology (Indian J Physiol Pharmacol), published in INDIA. (Language: eng)

Reference: 1995-Oct; vol 39 (issue 4) : pp 415-7

Dates: Created 1996/03/19; Completed 1996/03/19; Revised 2006/11/15;

PMID: 8582758, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

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