Research article summary (published 20 Apr 1996):

Reduced long-term potentiation in the dentate gyrus of mGlu1 receptor-mutant mice in vivo.

Full Abstract

Long-term potentiation in the dentate gyrus was studied in vivo in mutant mice lacking the metabotropic glutamate (mGlu) subtype 1 receptor. Long-term potentiation was induced in wild type animals (n = 7), but was reduced in mice lacking this receptor subtype (n = 7). These data suggest that mGlu receptors may be involved in the induction or maintenance of synaptic plasticity or that these receptors are required during development to establish this plasticity.

Author information

Author/s: Bordi, F (F);

Affiliation: Pharmacology Department, Glaxo-Wellcome Research Laboratories, Verona, Italy. fb23261(-atsign-)ggr.co.uk

Journal and publication information

Publication Type: Journal Article

Journal: European journal of pharmacology (Eur J Pharmacol), published in NETHERLANDS. (Language: eng)

Reference: 1996-Apr; vol 301 (issue 1-3) : pp R15-6

Dates: Created 1997/02/04; Completed 1997/02/04; Revised 2003/11/14;

PMID: 8773471, status: MEDLINE (last retrieved date: 2/18/2009)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MeSH Headings (categories) shown below.

Animals Dentate Gyrus - cytology; metabolism Long-Term Potentiation - genetics; physiology

Male Mice Receptors, Glutamate - genetics; metabolism

Note: Bold headings indicate primary MeSH headings or qualifiers.

Associated Chemicals: Receptors, Glutamate (0)

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